Subject and purpose of work: The purpose of the article is to assess the determinants of the structural and spatial transformation of the economy of Ukraine in a regional context. Materials and methods: The information base of the study was official data from the State Statistics Service of Ukraine. Results: Vectors of development of basic types of economic activity, in particular, industry, agriculture, trade, and construction, were established in comparison with the losses incurred in the conditions of a full-scale war. The emphasis was on the positive transformation of the structure of output of industrial and, in particular, metallurgical products in Ukraine. Conclusions: Despite significant losses and destruction as a result of a full-scale war, the economy of Ukraine is gradually recovering. All basic types of economic activity demonstrate positive development dynamics. The prospects for further development of the Ukrainian economy lie in the plane of neo-industrialization.