Subject and purpose of work: The present work aspires to observe major macroeconomic, institutional, and political factors determining the FDI inflows in BRICS countries. Materials and methods: The study employs Fixed effect, FGLS, and Prais-Winston panel corrected models to investigate the components determining FDI inflows in BRICS countries from 1997–2021. Results: Results suggest that among macroeconomic variables, gross fixed capital formation, human capital, trade openness and GDP growth significantly determine FDI inflows in the BRICS countries. Whereas, among Political variables, government effectiveness and regulatory quality significantly determine FDI inflows. As for institutional variables, only control of corruption significantly affects FDI inflows. Conclusions: The findings conclude that enhancing human capital by providing quality education and skills will increase FDI inflows. Also, creating a business-friendly environment through regular public-private dialogues and providing basic facilities to investors/MNCs is expected to enhance the FDI inflows. From a managerial perspective, it is important to assess the regulatory framework and the quality of various potential sectors.